Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses.

ABSTRACT: Human respiratory syncytial virus (RSV) is the most important cause of acute lower respiratory tract disease in infants worldwide. As a first line of defense against respiratory infections, innate immune responses, including the production of type I and III interferons (IFNs), play an important role. Upon infection with RSV, multiple pattern recognition receptors (PRRs) can recognize RSV-derived pathogen-associated molecular patterns (PAMPs) and mount innate immune responses. Retinoic-acid-inducible gene-I (RIG-I) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) have been identified as important innate receptors to mount type I IFNs during RSV infection. However, type I IFN levels remain surprisingly low during RSV infection despite strong viral replication. The po

SUBMITTER: Sedeyn K 

PROVIDER: S-EPMC6797084 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature