Project description:Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.

2018-12-18 | GSE123943 | GEO

The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia.

Project description: Not available

| S-EPMC12568422 | biostudies-literature

Prognostic value of serum lipids in newly diagnosed acute promyelocytic leukemia.

Project description: Not available

| S-EPMC11876187 | biostudies-literature

Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia.

Project description: Not available

| S-EPMC9768963 | biostudies-literature

The Prognostic Value and Function of HOXB5 in Acute Myeloid Leukemia.

Project description: Not available