Acute interventions for aggression and agitation in psychosis: study protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Individuals with psychosis may access emergency services due to aggression and agitation. When the de-escalation technique fails to achieve tranquillisation, several pharmacological options are available. However, evidence on which intervention to prefer in terms of efficacy and tolerability to achieve resolution of the acute episode (ie, rapid tranquillisation) of aggression and agitation is currently fragmentary.

Methods and analysis

We will include all randomised controlled trials comparing drugs or drug combinations or placebo for aggression or agitation episodes in adult individuals with psychosis. We will include individuals with psychosis (eg, schizophrenia and related disorders, bipolar disorder with psychotic symptoms, psychotic depression) but not subs

SUBMITTER: Ostinelli EG 

PROVIDER: S-EPMC6797276 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature