Anti-diabetic agents for prevention of type 2 diabetes mellitus in people with pre-diabetes: a systematic review and network meta-analysis protocol.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2DM) is a substantial health problem worldwide. Pre-diabetic state is associated with increased risk for the development of diabetes. There are various pharmacological therapies with glucose-lowering activity for diabetes prevention. Of those, most are being compared with placebo instead of active agents. The relative effects and safety of different glucose-lowering drugs still remain uncertain. To address this gap, we will conduct a systematic review and network meta-analysis (NMA) to evaluate comparative efficacy and safety of glucose-lowering agents for T2DM prevention in patients with pre-diabetes.

Methods and analysis

PubMed, the Cochrane library and Embase will be searched from inception to December 2019 for relevant randomised c

SUBMITTER: Wang X 

PROVIDER: S-EPMC6797281 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature