Which orthopaedic trauma patients are likely to refuse to participate in a clinical trial? A latent class analysis.

ABSTRACT:

Objective

The study aimed to assess systematic differences in the characteristics of patients that consented for the trial compared with the broader pool of eligible patients in a large, pragmatic orthopaedic trauma trial.

Design

A retrospective observational study performed from April 2017 to March 2018.

Setting

Academic trauma centre in Baltimore, USA.

Participants

There were 642 eligible adult trial participants with an operative fracture to the appendicular skeleton and were indicated for blood clot prophylaxis. The median age of the sample was 50 years (IQR: 31-63), and 60% were male.

Primary outcome measure

The primary outcome was the refusal to enrol in the trial. Demographic and injury covariates were included in iterations of latent class models

SUBMITTER: O'Hara NN 

PROVIDER: S-EPMC6797323 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature