Colorectal cancer screening with faecal testing, sigmoidoscopy or colonoscopy: a systematic review and network meta-analysis.

ABSTRACT: OBJECTIVE:Evaluate effectiveness, harms and burdens of faecal blood testing, sigmoidoscopy and colonoscopy screening for colorectal cancer over 15 years. DESIGN:We performed an update of a Cochrane systematic review, and performed network meta-analysis comparing randomised trials evaluating colorectal cancer screening with guaiac faecal occult blood test (gFOBT) (annual, biennial), faecal immunochemical test (FIT) (annual, biennial), sigmoidoscopy (once-only) or colonoscopy (once-only) in a healthy population, aged 50-79 years. We conducted subgroup analysis on sex. Follow-up >5 years was required for analysis of colorectal cancer incidence and mortality. RESULTS:12 randomised trials proved eligible. Compared with no-screening, we found high certainty evidence for sigmoidoscopy screening s

SUBMITTER: Jodal HC 

PROVIDER: S-EPMC6797379 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature