Long-term effect of azithromycin in bronchiolitis obliterans syndrome.

ABSTRACT:

Introduction

Azithromycin stabilises and improves lung function forced expiratory volume in one second (FEV₁) in lung transplantation patients with bronchiolitis obliterans syndrome (BOS). A post hoc analysis was performed to assess the long-term effect of azithromycin on FEV₁, BOS progression and survival .

Methods

Eligible patients recruited for the initial randomised placebo-controlled trial received open-label azithromycin after 3 months and were followed up until 6 years after inclusion (n=45) to assess FEV₁, BOS free progression and overall survival.

Results

FEV₁ in the placebo group improved after open-label azithromycin and was comparable with the treatment group by 6 months. FEV₁ decreased after 1 and 5 y

SUBMITTER: Gan CT 

PROVIDER: S-EPMC6797396 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature