Investigating imaging network markers of cognitive dysfunction and pharmacoresistance in newly diagnosed epilepsy: a protocol for an observational cohort study in the UK.

ABSTRACT:

Introduction

Epilepsy is one of the most common serious brain disorders, characterised by seizures that severely affect a person's quality of life and, frequently, their cognitive and mental health. Although most existing work has examined chronic epilepsy, newly diagnosed patients present a unique opportunity to understand the underlying biology of epilepsy and predict effective treatment pathways. The objective of this prospective cohort study is to examine whether cognitive dysfunction is associated with measurable brain architectural and connectivity impairments at diagnosis and whether the outcome of antiepileptic drug treatment can be predicted using these measures.

Methods and analysis

107 patients with newly diagnosed focal epilepsy from two National Health Service T

SUBMITTER: de Bezenac C 

PROVIDER: S-EPMC6797398 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature