Systematic review protocol on Bacillus Calmette-Guerin (BCG) revaccination and protection against tuberculosis.

ABSTRACT: INTRODUCTION:Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (M.TB) and other species of the Mycobacterium tuberculosis complex. Globally, TB is ranked as the ninth leading cause of death and the leading cause of death from a single infectious agent. The bacille Calmette-Guerin (BCG) vaccine has been used globally since 1921 for the prevention of TB in humans, and was derived from an attenuated strain of Mycobacterium bovis. Evidence from previous randomised trials show that the efficacy of primary BCG vaccination against pulmonary TB ranged from no protection to very high protection. In addition, some studies suggest a benefit of BCG revaccination. For example, a recent trial conducted in South Africa showed that BCG revaccination of adolescents could reduce the risk o

SUBMITTER: Mahasha PW 

PROVIDER: S-EPMC6797475 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature