Ontology highlight
ABSTRACT:
SUBMITTER: Tassetto M
PROVIDER: S-EPMC6797480 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Tassetto Michel M Kunitomi Mark M Whitfield Zachary J ZJ Dolan Patrick T PT Sánchez-Vargas Irma I Garcia-Knight Miguel M Ribiero Isabel I Chen Taotao T Olson Ken E KE Andino Raul R
eLife 20191017
<i>Aedes aegypti</i> transmit pathogenic arboviruses while the mosquito itself tolerates the infection. We examine a piRNA-based immunity that relies on the acquisition of viral derived cDNA (vDNA) and how this pathway discriminates between self and non-self. The piRNAs derived from these vDNAs are essential for virus control and Piwi4 has a central role in the pathway. Piwi4 binds preferentially to virus-derived piRNAs but not to transposon-targeting piRNAs. Analysis of episomal vDNA from infec ...[more]