Long non-coding RNA HCG11 modulates glioma progression through cooperating with miR-496/CPEB3 axis.

ABSTRACT:

Objectives

It has been widely reported that long non-coding RNAs (lncRNAs) can participate in multiple biological processes of human cancers. lncRNA HLA complex group 11 (HCG11) has been reported in human cancers as a tumour suppressor. This study focused on investigating the function and mechanism of HCG11 in glioma.

Materials and methods

Based on The Cancer Genome Atlas (TCGA) data set and qRT-PCR analysis, the expression pattern of HCG11 was identified in glioma samples. The mechanism associated with HCG11 downregulation was determined by mechanism experiments. Gain-of-function assays were conducted for the identification of HCG11 function in glioma progression. Mechanism investigation based on the luciferase reporter assay, RIP assay and pull-down assay was used to explo

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6797506 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature