FER promotes cell migration via regulating JNK activity.

ABSTRACT:

Objectives

Cell migration has a key role in cancer metastasis, which contributes to drug resistance and tumour recurrence. Better understanding of the mechanisms involved in this process will potentially reveal new drug targets for cancer therapy. Fer is a non-receptor protein tyrosine kinase aberrantly expressed in various human cancers, whereas its role in tumour progression remains elusive.

Materials and methods

Transgenic flies and epigenetic analysis were employed to investigate the role of Drosophila Fer (FER) in cell migration and underlying mechanisms. Co-immunoprecipitation assay was used to monitor the interaction between FER and Drosophila JNK (Bsk). The conservation of Fer in regulating JNK signalling was explored in mammalian cancer and non-cancer cells.

Resu

SUBMITTER: Li P 

PROVIDER: S-EPMC6797522 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature