Efficacy and safety of different fractions in stereotactic body radiotherapy for spinal metastases: A systematic review.

ABSTRACT:

Background

In the treatment of spinal metastases, stereotactic body radiotherapy (SBRT) delivers precise, high-dose radiation to the target region while sparing the spinal cord. A range of doses and fractions had been reported; however, the optimal prescribed scheme remains unclear.

Methods

Two reviewers performed independent literature searches of the PubMed, EMBASE, Cochrane Database, and Web of Science databases. Articles were divided into one to five fractions groups. The Methodological Index for Non-randomized Studies (MINORS) was used to assess the quality of studies. Local control (LC) and overall survival (OS) were presented for the included studies and a pooled value was calculated by the weighted average.

Results

The 38 included studies comprised 3,754 patie

SUBMITTER: Gong Y 

PROVIDER: S-EPMC6797563 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature