NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function.

ABSTRACT: Over the last decade, significant progress has been achieved in defining mechanisms underlying NLR regulation of immune system function. However, several NLR family members continue to defy our best attempts at characterization and routinely exhibit confounding data. This is particularly true for NLR family members that regulate signaling associated with the activation of other pattern recognition receptors. NLRX1 is a member of this NLR sub-group and acts as an enigmatic regulator of immune system function. NLRX1 has been shown to negatively regulate type-I interferon, attenuate pro-inflammatory NF-κB signaling, promote reactive oxygen species production, and modulate autophagy, cell death, and proliferation. However, the mechanism/s associated with NLRX1 modulation of these pathways is n

SUBMITTER: Nagai-Singer MA 

PROVIDER: S-EPMC6797603 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature