Brainglance: Visualizing Group Level MRI Data at One Glance.

ABSTRACT: The vast majority of studies using functional magnetic resonance imaging (fMRI) are analyzed on the group level. Standard group-level analyses, however, come with severe drawbacks: First, they assume functional homogeneity within the group, building on the idea that we use our brains in similar ways. Second, group-level analyses require spatial warping and substantial smoothing to accommodate for anatomical variability across subjects. Such procedures massively distort the underlying fMRI data, which hampers the spatial specificity. Taken together, group statistics capture the effective overlap, rendering the modeling of individual deviations impossible - a major source of false positivity and negativity. The alternative analysis approach is to leave the data in the native subject space, b

SUBMITTER: Stelzer J 

PROVIDER: S-EPMC6797611 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature