Lymph node metastasis in lung squamous cell carcinoma and identification of metastasis-related genes based on the Cancer Genome Atlas.

ABSTRACT: Squamous cell carcinoma (SCC) is a unique clinical and histological category that accounts for about 30% of total lung cancer. To identify risk factors for lymph node metastasis and analyze the molecular features of these metastases in lung SCC, a retrospective study was performed for 170 lung SCC patients who underwent surgical treatment. The overall survival of these patients with or without lymph node metastasis (LM/NLM) was analyzed using the Kaplan-Meier method. We also used the TCGA database to compare the differentially expressed genes (DEGs) in patients with stage T1-2 and T3-4 lung SCC. Data from both our retrospective study and the TCGA database demonstrated a correlation between age and stage T1-T2 LM (P = .002). There were significant differences between the LM and NLM groups i

SUBMITTER: Dong M 

PROVIDER: S-EPMC6797670 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature