Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest.

ABSTRACT: BACKGROUND:Growth differentiation factor 15 (GDF-15) is an inflammatory cytokine released in response to tissue injury. It has prognostic value in cardiovascular diseases and other acute and chronic conditions. Here, we explored the value of GDF-15 as an early predictor of neurologic outcome after an out-of-hospital cardiac arrest (OHCA). METHODS:Prospective registry study of patients in coma after an OHCA, admitted in the intensive cardiac care unit from a single university center. Serum levels of GDF-15 were measured on admission. Neurologic status was evaluated according to the cerebral performance category (CPC) scale. The relationship between GDF-15 levels and poor neurologic outcome at 6 months was analyzed. RESULTS:Among 62 patients included, 32 (51.6%) presented poor outcome (CPC 3

SUBMITTER: Rueda F 

PROVIDER: S-EPMC6797678 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature