Ontology highlight
ABSTRACT:
SUBMITTER: Dong J
PROVIDER: S-EPMC6797737 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature communications 20191017 1
DNA methylation, repressive histone marks, and PIWI-interacting RNA (piRNA) are essential for the control of retrotransposon silencing in the mammalian germline. However, it remains unknown how these repressive epigenetic pathways crosstalk to ensure retrotransposon silencing in the male germline. Here, we show that UHRF1 is responsible for retrotransposon silencing and cooperates with repressive epigenetic pathways in male germ cells. Conditional loss of UHRF1 in postnatal germ cells causes DNA ...[more]