Control of Ion Transport by Tmem16a Expressed in Murine Intestine.

ABSTRACT: Cl^- secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca²⁺ activated Cl^- channel Tmem16a was shown to contribute to Cl^- secretion, mainly, but not exclusively, as a basolaterally located Cl^- channel that controls basolateral Ca²⁺ signaling, and thus activation of basolateral Ca²⁺ dependent Sk4 K⁺ channels. In intestinal goblet cells, Tmem16a was shown to regulated Ca²⁺ signals required for exocytosis of mucus. Because a recent report denied the existence and functional role of Tmem16a in murine intestine, we reexamined in detail expression of mRNA and protein for Tmem16a in mouse colon. In experi

SUBMITTER: Kunzelmann K 

PROVIDER: S-EPMC6797858 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature