The role of CCR1 and therapeutic effects of anti-CCL3 antibody in herpes simplex virus-induced Behcet's disease mouse model.

ABSTRACT: Behçet's disease (BD) is a chronic systemic inflammatory disease with unclear etiopathogenesis. Although gene variants of CC chemokine receptor type 1 (CCR1) have been reported, the protein expression of CCR1 in patients with BD remains unclear. The objective of this study was to analyze the frequencies of CCR1⁺ cells in a herpes simplex virus-induced mouse model of BD. The frequencies of CCR1⁺ cells on the surface and in the cytoplasm of peripheral blood mononuclear cells and lymph nodes were analyzed by flow cytometry. The CCR1⁺ cells were significantly down-regulated in BD mice compared with the normal control and symptom-free control mice. Colchicine and pentoxifylline treatment improved the symptoms of BD and increased the frequencies of CCR1⁺

SUBMITTER: Sayeed HM 

PROVIDER: S-EPMC6797864 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature