Hippocampal-Cortical Memory Trace Transfer and Reactivation Through Cell-Specific Stimulus and Spontaneous Background Noise.

ABSTRACT: The hippocampus plays important roles in memory formation and retrieval through sharp-wave-ripples. Recent studies have shown that certain neuron populations in the prefrontal cortex (PFC) exhibit coordinated reactivations during awake ripple events. These experimental findings suggest that the awake ripple is an important biomarker, through which the hippocampus interacts with the neocortex to assist memory formation and retrieval. However, the computational mechanisms of this ripple based hippocampal-cortical coordination are still not clear due to the lack of unified models that include both the hippocampal and cortical networks. In this work, using a coupled biophysical model of both CA1 and PFC, we investigate possible mechanisms of hippocampal-cortical memory trace transfer and the c

SUBMITTER: Liu X 

PROVIDER: S-EPMC6798041 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature