Autism Spectrum Disorders and Perinatal Complications-Is Oxidative Stress the Connection?

ABSTRACT: Background: Autism spectrum disorders (ASD) are complex psychiatric disorders, with gene environment interaction being in the basis of their etiology. The association of perinatal complications and ASD is well established. Recent findings suggested that oxidative stress and polymorphism in genes encoding antioxidant enzymes might be involved in the development of ASD. Glutathione transferases (GSTs) have an important role in the antioxidant defense system. We aimed to establish whether the predictive effects of prenatal and perinatal complications (as possible oxidative stress inducers) on ASD risk are dependent on GST polymorphisms. Methods: The study included 113 ASD cases and 114 age- and sex group-matched healthy controls. All participants were genotyped for GSTA1, GSTM1,

SUBMITTER: Mandic-Maravic V 

PROVIDER: S-EPMC6798050 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature