Three Novel Loci for Infant Head Circumference Identified by a Joint Association Analysis.

ABSTRACT: As an important trait at birth, infant head circumference (HC) is associated with a variety of intelligence- and mental-related conditions. Despite being dominated by genetics, the mechanism underlying the variation of HC is poorly understood. Aiming to uncover the genetic basis of HC, we performed a genome-wide joint association analysis by integrating the genome-wide association summary statistics of HC with that of its two related traits, birth length and birth weight, using a recently developed integrative method, multitrait analysis of genome-wide association (MTAG), and performed in silico replication in an independent sample of intracranial volume (N = 26,577). We then conducted a series of bioinformatic investigations on the identified loci. Combining the evidence fro

SUBMITTER: Yang XL 

PROVIDER: S-EPMC6798153 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature