ITRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: biomarkers discovery.

ABSTRACT:

Background

Early recurrent spontaneous abortion (ERSA) is a common condition in pregnant women. To prevent ERSA is necessary to look for abortion indicators, such as hormones and proteins, in an early stage.

Methods

Thirty patients with ERSA were enrolled in the case group. In the control group, we recruited 30 healthy women without a history of miscarriage undergoing voluntary pregnancy termination. The differentially expressed proteins in the serum were identified between the two groups using PRM and iTRAQ.

Results

Seventy-eight differentially expressed proteins were identified. Using GO functional annotation and KEGG pathway analysis, we detected that the most significant changes occurred in the pathway of Fc gamma R-mediated phagocytosis. Meanwhile, using PRM, we

SUBMITTER: Cui Y 

PROVIDER: S-EPMC6798364 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature