The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium.

ABSTRACT:

Background

The rapid identification of lineage remains a challenge in the genotyping of clinical isolates of recombinogenic pathogens. The chromosome of Mycobacterium avium subsp. hominissuis (MAH), an agent of Mycobacterium avium complex (MAC) lung disease, is often mosaic and is composed of chromosomal segments originating from different lineages. This makes it difficult to infer the MAH lineage in a simple experimental set-up. To overcome this difficulty, we sought to identify chromosomal marker genes containing lineage-specific alleles by genome data mining.

Results

We conducted genetic population structure analysis, phylogenetic analysis, and a survey of historical recombination using data from 125 global MAH isolates. Six MAH lineages (EA1, EA2, SC1, SC2, SC3, and SC4)

SUBMITTER: Yano H 

PROVIDER: S-EPMC6798384 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature