Repertoire-wide gene structure analyses: a case study comparing automatically predicted and manually annotated gene models.

ABSTRACT: BACKGROUND:The location and modular structure of eukaryotic protein-coding genes in genomic sequences can be automatically predicted by gene annotation algorithms. These predictions are often used for comparative studies on gene structure, gene repertoires, and genome evolution. However, automatic annotation algorithms do not yet correctly identify all genes within a genome, and manual annotation is often necessary to obtain accurate gene models and gene sets. As manual annotation is time-consuming, only a fraction of the gene models in a genome is typically manually annotated, and this fraction often differs between species. To assess the impact of manual annotation efforts on genome-wide analyses of gene structural properties, we compared the structural properties of protein-coding genes

SUBMITTER: Wilbrandt J 

PROVIDER: S-EPMC6798390 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature