Dataset Information

Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.

ABSTRACT:

Background

Exposure to blacklegged ticks Ixodes scapularis that transmit pathogens is thought to occur peri-domestically. However, the locations where people most frequently encounter infected ticks are not well characterized, leading to mixed messages from public health officials about where risk is highest.

Methods

We conducted a systematic review and meta-analysis on spatial risk factors for tick-borne disease and tick bites in eastern North America. We examined three scales: the residential yard, the neighborhood surrounding (but not including) the yard, and outside the neighborhood. Nineteen eligible studies represented 2741 cases of tick-borne illness and 1447 tick bites. Using random effects models, we derived pooled odds ratio (OR) estimates.

Results

The meta-analysis revealed significant disease risk factors at the scale of the yard (OR 2.60 95% CI 1.96 - 3.46), the neighborhood (OR 4.08 95% CI 2.49 - 6.68), and outside the neighborhood (OR 2.03 95% CI 1.59 - 2.59). Although significant risk exists at each scale, neighborhood scale risk factors best explained disease exposure. Analysis of variance revealed risk at the neighborhood scale was 57% greater than risk at the yard scale and 101% greater than risk outside the neighborhood.

Conclusions

This analysis emphasizes the importance of understanding and reducing tick-borne disease risk at the neighborhood scale. Risk-reducing interventions applied at each scale could be effective, but interventions applied at the neighborhood scale are most likely to protect human health.

Trial registration

The study was registered with PROSPERO: CRD42017079169 .

SUBMITTER: Fischhoff IR

PROVIDER: S-EPMC6798452 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.

Fischhoff Ilya R IR Bowden Sarah E SE Keesing Felicia F Ostfeld Richard S RS

BMC infectious diseases 20191017 1

<h4>Background</h4>Exposure to blacklegged ticks Ixodes scapularis that transmit pathogens is thought to occur peri-domestically. However, the locations where people most frequently encounter infected ticks are not well characterized, leading to mixed messages from public health officials about where risk is highest.<h4>Methods</h4>We conducted a systematic review and meta-analysis on spatial risk factors for tick-borne disease and tick bites in eastern North America. We examined three scales: t ...[more]

PMID: 31623574

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Dataset Information

Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.

Background

Methods

Results

Conclusions

Trial registration

Publications

Systematic review and meta-analysis of tick-borne disease risk factors in residential yards, neighborhoods, and beyond.

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