Expressed proteins and activated pathways in conditioned embryo culture media from IVF patients are diverse according to infertility factors.

ABSTRACT: OBJECTIVE:Given that the embryo culture medium secretome reflects the embryo development, we hypothesize that protein profiles are affected according to infertility factors, which can be responsible for detrimental embryonic developmental competence. The aim of this study was to screen the protein profile of conditioned embryo culture media in patients presenting deep infiltrating endometriosis (ENDO) and polycystic ovarian syndrome (PCOS) undergoing IVF, by proteomics approaches. The control group was constituted by tubal factor patients. METHODS:Patients underwent in vitro fertilization (IVF) treatment as routine and oocytes were fertilized by ICSI. The embryos were group cultured until day 3 of development, and after transfer the culture media were collected. For the proteomics analysis

SUBMITTER: Bonetti TC 

PROVIDER: S-EPMC6798601 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature