Association between reduced brain-derived neurotrophic factor concentration & coronary heart disease.

ABSTRACT: Background & objectives:Brain-derived neurotrophic factor (BDNF) facilitates neuronal survival, differentiation and synaptic connectivity and affects neurotransmission throughout the brain. However, it has also a modulatory role in energy homeostasis, obesity and cardiovascular function. Obesity, high body mass index (BMI) and dyslipidaemia, among other factors, contribute to coronary heart disease (CHD) development. The exact role of BDNF in development of CHD is not well defined. This study was aimed to evaluate if plasma BDNF concentration was associated with CHD in ethnically homogeneous groups of patients and to correlate plasma BDNF levels with known risk factors for CHD. Methods:Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk facto

SUBMITTER: Sustar A 

PROVIDER: S-EPMC6798606 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature