Associations of rs524952 and rs634990 gene polymorphisms in 15q14 with high myopia: A meta-analysis.

ABSTRACT: Purpose:Many studies have been conducted to investigate the association between the rs524952 and rs634990 polymorphisms and high myopia (HM). However, the results were conflicting. Thus, a meta-analysis was needed to reveal the real association between the two single nucleotide polymorphisms (SNPs) and HM. Methods:All eligible studies published in Pubmed, Embase, China Biologic Medicine (CBM), the China National Knowledge Infrastructure (CNKI), the Cochrane Library, and the Web of Science from 2010 to March 2019 were examined. Results:Six comparison groups in four studies with 5,293 subjects for the rs524952 polymorphism and five studies with 6,750 subjects for the rs634990 polymorphism were included. No statistically significant associations were observed between the rs524952 and rs634990

SUBMITTER: Xu C 

PROVIDER: S-EPMC6798703 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature