Effectiveness of extended- versus normal-release nitrofurantoin for cystitis: an instrumental variable analysis.

ABSTRACT: BACKGROUND:It is unknown whether nitrofurantoin 50 mg normal-release every 6 h (NF50) and nitrofurantoin 100 mg extended-release every 12 h (NF100) are equally effective for treating cystitis in primary care. In the Netherlands, GP prescription of either option largely depends on pharmacy procurement, rather than on patient-related factors. METHODS:GP data between January 2013 and July 2018 were retrospectively collected. Inclusion criteria were the use of nitrofurantoin for uncomplicated cystitis, complicated cystitis or cystitis in pregnancy. Criteria for early and late failure were a second antibiotic prescription for cystitis or pyelonephritis within 14 and 28 days post-prescription, respectively. Crude and confounder-adjusted (CA) risk differences (RDs) were estimated using linear reg

SUBMITTER: Ten Doesschate T 

PROVIDER: S-EPMC6798831 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature