Customizing droplet contents and dynamic ranges via integrated programmable picodroplet assembler.

ABSTRACT: Droplet microfluidic technology is becoming increasingly useful for high-throughput and high-sensitivity detection of biological and biochemical reactions. Most current droplet devices function by passively discretizing a single sample subject to a homogeneous or random reagent/reaction condition into tens of thousands of picoliter-volume droplets for analysis. Despite their apparent advantages in speed and throughput, these droplet devices inherently lack the capability to customize the contents of droplets in order to test a single sample against multiple reagent conditions or multiple samples against multiple reagents. In order to incorporate such combinatorial capability into droplet platforms, we have developed the fully Integrated Programmable Picodroplet Assembler. Our platform is c

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6799804 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature