Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing.

ABSTRACT: We present a simple and customizable microneedle mold fabrication technique using a low-cost desktop SLA 3D printer. As opposed to conventional microneedle fabrication methods, this technique neither requires complex and expensive manufacturing facilities nor expertise in microfabrication. While most low-cost 3D-printed microneedles to date display low aspect ratios and poor tip sharpness, we show that by introducing a two-step "Print & Fill" mold fabrication method, it is possible to obtain high-aspect ratio sharp needles that are capable of penetrating tissue. Studying first the effect of varying design input parameters and print settings, it is shown that printed needles are always shorter than specified. With decreasing input height, needles also begin displaying an increasingly greate

SUBMITTER: Krieger KJ 

PROVIDER: S-EPMC6799892 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature