Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study.

ABSTRACT:

Background

Information is needed on the safety of adalimumab when used in pregnancy for the treatment of certain autoimmune diseases.

Methods and findings

Between 2004 and 2016, the Organization of Teratology Information Specialists Research Center at the University of California San Diego conducted a prospective controlled observational cohort study in 602 pregnant women who had or had not taken adalimumab. Women in the adalimumab-exposed cohort had received at least one dose of the drug in the first trimester for the treatment of rheumatoid arthritis or Crohn's Disease (N = 257). Women in the disease comparison cohort had not used adalimumab in pregnancy (N = 120). Women in the healthy comparison cohort had no rheumatic or inflammatory bowel diseases (N = 225). Women and t

SUBMITTER: Chambers CD 

PROVIDER: S-EPMC6799916 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature