Effect of Particle Formation Process on Characteristics and Aerosol Performance of Respirable Protein Powders.

ABSTRACT: Pulmonary delivery of biopharmaceuticals may enable targeted local therapeutic effect and noninvasive systemic administration. Dry powder inhaler (DPI) delivery is an established patient-friendly approach for delivering large molecules to the lungs; however, the complexities of balancing protein stability with aerosol performance require that the design space of biopharmaceutical DPI formulations is rigorously explored. Utilizing four rationally selected formulations obtained using identical atomization conditions, an extensive study of the effect of the particle formation process (spray drying or spray freeze-drying) on powder properties, aerosol performance, and protein stability was performed. Multiple linear regression analysis was used to understand the relationship between powder pro

SUBMITTER: Brunaugh AD 

PROVIDER: S-EPMC6800019 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature