Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications.

ABSTRACT:

Objective

Mild cognitive impairment (MCI) is associated with increased memory problems although the ability to complete daily life activities remains relatively intact. This study examined: (1) if sleep disturbance increased the hazard of MCI; (2) if APOE e4 carriers with sleep disturbance experience an increased risk of MCI; and, (3) if prescription sleep medications provide a protective effect against MCI. We hypothesized that sleep disturbance increases the hazard of MCI, this relationship is stronger among APOE e4 carriers reporting a sleep disturbance. Furthermore, we hypothesized that sleep medications decrease the hazard of MCI.

Methods

To determine whether sleep medication mediates the risk of developing MCI for individuals with sleep disturbance and/or APOE _e4<

SUBMITTER: Burke SL 

PROVIDER: S-EPMC6800075 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature