Implications of juvenile idiopathic arthritis genetic risk variants for disease pathogenesis and classification.

ABSTRACT:

Purpose of review

We assess the implications of recent advances in the genetics of juvenile idiopathic arthritis (JIA) for the evolving understanding of inflammatory arthritis in children.

Recent findings

JIA exhibits prominent genetic associations with the human leukocyte antigen (HLA) region, extending perhaps surprisingly even to the hyperinflammatory systemic JIA category. Some HLA associations resemble those for adult-onset inflammatory arthritides, providing evidence for pathogenic continuity across the age spectrum. Genome-wide association studies have defined an increasing number of JIA-linked non-HLA loci, many again shared with adult-onset arthritis. As most risk loci contain only noncoding variants, new experimental methods such as SNP-seq and innovative big-data

SUBMITTER: Nigrovic PA 

PROVIDER: S-EPMC6800096 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature