Ontology highlight
ABSTRACT:
SUBMITTER: Brigidi GS
PROVIDER: S-EPMC6800120 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell 20191001 2
Cells regulate gene expression in response to salient external stimuli. In neurons, depolarization leads to the expression of inducible transcription factors (ITFs) that direct subsequent gene regulation. Depolarization encodes both a neuron's action potential (AP) output and synaptic inputs, via excitatory postsynaptic potentials (EPSPs). However, it is unclear if distinct types of electrical activity can be transformed by an ITF into distinct modes of genomic regulation. Here, we show that APs ...[more]