Genome-wide meta-analysis reveals shared new <i>loci</i> in systemic seropositive rheumatic diseases.

ABSTRACT:

Objective

Immune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex conditions with overlapping clinical symptoms and elevated familial aggregation, which suggests the existence of a shared genetic component. In order to identify this genetic background in a systematic fashion, we performed the first cross-disease genome-wide meta-analysis in systemic seropositive rheumatic diseases, namely, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and idiopathic inflammatory myopathies.

Methods

We meta-analysed ~6.5 million single nucleotide polymorphisms in 11 678 cases and 19 704 non-affected controls of European descent populations. The functional roles of the associated variants were interrogated using publicly available databases.

Resu

SUBMITTER: Acosta-Herrera M 

PROVIDER: S-EPMC6800208 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature