Splicing regulatory factors in breast cancer hallmarks and disease progression.

ABSTRACT: By regulating transcript isoform expression levels, alternative splicing provides an additional layer of protein control. Recent studies show evidence that cancer cells use different splicing events to fulfill their requirements in order to develop, progress and metastasize. However, there has been less attention for the role of the complex catalyzing the complicated multistep splicing reaction: the spliceosome. The spliceosome consists of multiple sub-complexes in total comprising 244 proteins or splice factors and 5 associated RNA molecules. Here we discuss the role of splice factors in the oncogenic processes tumors cells need to fulfill their oncogenic properties (the so-called the hallmarks of cancer). Despite the fact that splice factors have been investigated only recently, they see

SUBMITTER: Koedoot E 

PROVIDER: S-EPMC6800274 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature