β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea.

ABSTRACT: Development of multicellular organs requires the coordination of cell differentiation and patterning. Critical for sound detection, the mammalian organ of Corti contains functional units arranged tonotopically along the cochlear turns. Each unit consists of sensory hair cells intercalated by nonsensory supporting cells, both specified and radially patterned with exquisite precision during embryonic development. However, how cell identity and radial patterning are jointly controlled is poorly understood. Here we show that β-catenin is required for specification of hair cell and supporting cell subtypes and radial patterning of the cochlea in vivo. In 2 mouse models of conditional β-catenin deletion, early specification of Myosin7-expressing hair cells and Prox1-positive supporting cells was

SUBMITTER: Jansson L 

PROVIDER: S-EPMC6800344 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature