Gradients of structure-function tethering across neocortex.

ABSTRACT: The white matter architecture of the brain imparts a distinct signature on neuronal coactivation patterns. Interregional projections promote synchrony among distant neuronal populations, giving rise to richly patterned functional networks. A variety of statistical, communication, and biophysical models have been proposed to study the relationship between brain structure and function, but the link is not yet known. In the present report we seek to relate the structural and functional connection profiles of individual brain areas. We apply a simple multilinear model that incorporates information about spatial proximity, routing, and diffusion between brain regions to predict their functional connectivity. We find that structure-function relationships vary markedly across the neocortex. Struc

SUBMITTER: Vazquez-Rodriguez B 

PROVIDER: S-EPMC6800358 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature