Skin Autofluorescence Measurement in Subclinical Atheromatous Disease: Results from the ILERVAS Project.

ABSTRACT: AIM:Advanced glycation end-products (AGEs) have been involved in the atherogenic process in the high-risk population. The goal of this study was to demonstrate that AGEs are related to subclinical atheromatous disease in subjects with low to moderate vascular risk. METHODS:A cross-sectional study in which 2,568 non-diabetic subjects of both sexes without cardiovascular disease were included. Subcutaneous content of AGEs was assessed by skin autofluorescence (SAF) and subclinical atheromatous disease was measured by assessing the atheromatous plaque burden in carotid and femoral regions using ultrasonography. In addition, serum pentosidine, carboxymethyl-lysine (CML) and AGE receptors (RAGE) were assessed in a nested case-control study with 41 subjects without plaque and 41 individuals subj

SUBMITTER: Sanchez E 

PROVIDER: S-EPMC6800392 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature