Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis.

ABSTRACT:

Objective

More recent studies suggested that defects in autophagy contribute to the pathogenesis of SLE, especially in adaptive immunity. Occurrence and progression of lupus nephritis (LN) is the end result of complex interactions between regulation of immune responses and pathological process by renal resident cells, but there is still a lot of missing information for an establishment on the role of autophagy in pathogenesis of LN and as a therapy target.

Methods

Systemic and organ-specific aetiologies of autophagy were first evaluated by autophagy protein quantification in tissue homogenates in MRL ^lpr/lpr lupus prone and female C57BL mice. Analysis of gene expression was also adopted in human blood and urine sediments. Then, some key mediators of the dis

SUBMITTER: Qi YY 

PROVIDER: S-EPMC6800572 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature