Lytic transglycosylases RlpA and MltC assist in Vibrio cholerae daughter cell separation.

ABSTRACT: The cell wall is a crucial structural feature in the vast majority of bacteria and comprises a covalently closed network of peptidoglycan (PG) strands. While PG synthesis is important for survival under many conditions, the cell wall is also a dynamic structure, undergoing degradation and remodeling by 'autolysins', enzymes that break down PG. Cell division, for example, requires extensive PG remodeling, especially during separation of daughter cells, which depends heavily upon the activity of amidases. However, in Vibrio cholerae, we demonstrate that amidase activity alone is insufficient for daughter cell separation and that lytic transglycosylases RlpA and MltC both contribute to this process. MltC and RlpA both localize to the septum and are functionally redundant under normal laborato

SUBMITTER: Weaver AI 

PROVIDER: S-EPMC6800776 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature