Construction of a Frailty Index as a Novel Health Measure in Systemic Lupus Erythematosus.

ABSTRACT:

Objective

To construct a Frailty Index (FI) as a measure of vulnerability to adverse outcomes among patients with systemic lupus erythematosus (SLE), using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort.

Methods

The SLICC inception cohort consists of recently diagnosed patients with SLE followed annually with clinical and laboratory assessments. For this analysis, the baseline visit was defined as the first study visit at which sufficient information was available for construction of an FI. Following a standard procedure, variables from the SLICC database were evaluated as potential health deficits. Selected health deficits were then used to generate a SLICC-FI. The prevalence of frailty in the baseline dataset was evaluated using e

SUBMITTER: Legge A 

PROVIDER: S-EPMC6800806 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature