Association of Working Memory With Distributed Executive Control Networks in Schizophrenia.

ABSTRACT:

Objective

Working memory impairments represent a core cognitive deficit in schizophrenia, predictive of patients' daily functioning, and one that is unaffected by current treatments. To address this, working memory is included in the MATRICS Consensus Cognitive Battery (MCCB), a standardized cognitive battery designed to facilitate drug development targeting cognitive symptoms. However, the neurobiology underlying these deficits in MCCB working memory is currently unknown, mirroring the poor understanding in general of working memory deficits in schizophrenia.

Methods

Twenty-eight participants with schizophrenia were administered working memory tests from the MCCB and examined with resting-state functional MRI. Intrinsic connectivity networks were estimated with independent

SUBMITTER: Wylie KP 

PROVIDER: S-EPMC6800820 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature