Predictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy.

ABSTRACT:

Goals

The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD.

Background

Gastrin elevation is a known but variable consequence of proton pump inhibitor (PPI) therapy. Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation.

Study

This cross-sectional analysis included patients with endoscopically verified erosive esophagitis receiving long-term PPI therapy. PPI exposure in dosage over weight (mg/kg) and dosage over body surface area (mg/m) was compared with fasting gastrin levels in two separate multiple linear regression models. Data was collected on age, gender,

SUBMITTER: Helgadottir H 

PROVIDER: S-EPMC6800823 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature