Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.

ABSTRACT:

Background

Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality rates and poor prognosis. Signs and symptoms of GBC are not specific and often arise at late stage of disease. For this reason, diagnosis is typically made when the cancer is already in advanced stages, and prognosis for survival is less than 5 years in 90% of cases. Biomarkers to monitor disease progression and novel therapeutic alternative targets for these tumors are strongly required. Commonly, dysregulated protein synthesis contributes to carcinogenesis and cancer progression. In this case, protein synthesis directs translation of specific mRNAs, and, in turn, promotes cell survival, invasion, angiogenesis, and metastasis of tumors. In eukaryotes, protein synthesis is regulated at

SUBMITTER: Golob-Schwarzl N 

PROVIDER: S-EPMC6800842 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature