Pregnancy Hypertension and a Commonly Inherited IGF1R Variant (rs2016347) Reduce Breast Cancer Risk by Enhancing Mammary Gland Involution.

ABSTRACT:

Background

Terminal duct lobular units (TDLUs) are the anatomic sites of breast cancer initiation, and breast tissue involution resulting in lower TDLU counts has been associated with decreased breast cancer risk. The insulin-like growth factor (IGF) pathway plays a role in breast involution, and systemic changes in this developmental pathway occur with hypertensive disorders of pregnancy (HDP), which have also been associated with lower breast cancer risk, especially in women carrying a functional variant of IGF1R SNP rs2016347. We proposed that this breast cancer protective effect might be explained by increased breast tissue involution.

Materials and methods

We conducted a retrospective cohort study utilizing the Komen Tissue Bank, which collects breast tissue core biopsi

SUBMITTER: Powell MJ 

PROVIDER: S-EPMC6800903 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature